Bioactivity:CDK12-IN-E9 is a potent and selective covalent CDK12 inhibitor and non-covalent CDK9 inhibitor while avoiding ABC transporter-mediated efflux. It has a weak binding ability to CDK7/CyclinH complex (IC50> 1 _M).
CAS Nr:
2020052-55-3
Purity:
98%
SMILES:
C=CC(NC1=CC=CC(NC2=CC(N3[C@H](CCO)CCCC3)=NC4=C(CC)C=NN24)=C1)=O
Formula:
C24H30N6O2
Molecular weight:
434,53
Pathway:
Cell Cycle/Checkpoint
Target:
CDK