Bioactivity:Ciliobrevin D is a AAA+ ATPase motor cytoplasmic dynein inhibitor.ÊCiliobrevin D inhibits Hedgehog (Hh) signaling and primary cilia formation and it also inhibits dynein-dependent microtubule gliding and ATPase activity in vitro.
CAS Nr:
1370554-01-0
Purity:
98%
SMILES:
O=C(C1=C(C=C(Cl)C=C1)Cl)/C(C#N)=C(N2)/NC3=CC(Cl)=CC=C3C2=O
Formula:
C17H8Cl3N3O2
Molecular weight:
392,62
Pathway:
GPCR/G Protein,Stem Cells,Membrane transporter/Ion channel
Target:
Hedgehog/Smoothened,Hedgehog/Smoothened,ATPase